Assoc. Prof., Dept of Internal Medicine
University of Texas Medical Branch
Organization Web Site
Languages I speak
Please list your areas of Expertise
Summarize your expertise in greater detail
Dr. Savidge is the recipient of an NIH-ITS grant (Development of novel therapeutics for Clostridium difficile infection; 1UL1RR029876-01) and an Award from the John S. Dunn Gulf Coast Consortium for Chemical Genomics Robert A. Welch Collaborative Grant Program to use his expertise of GSNO chemistry and computational methods to develop novel therapeutic compounds for intestinal inflammation. In addition to Crohn's disease, these grants focus on Clostridium difficile-induced colitis, which is the leading cause of antibiotic-associated diarrhea and colonic inflammation in the United States. As Principal Investigator of an NIH-funded multidisciplinary team at UTMB, Dr. Savidge is initiating a clinical trial to assess whether disease amelioration is evident in patients with Clostridium difficile patients using methods that he has pioneered in his laboratory. The impact of developing effective oral small molecule therapy for such an important infectious pathogen is that this would provide an inexpensive and novel treatment option for a global epidemic that threatens to become one of the major public health concerns of the 21st century.
Books & Articles Published
Dr. Savidge has published over 60 articles, he has co-edited one book on Microbial Imaging and is currently editing a Special Highlights Topic on Clostridium difficile infection for the World Gastroenterology Journal where he currently serves as an Editorial Board Member.
Awards, Associations & Memberships
Dr. Savidge is a member of several international editorial boards and is assuming the Editor-in-Chief position for the Open Gastroenterology Journal (Benham STM Publishers) from 2011-2013.
Dr. Savidge also serves on the editorial Board of Frontiers in Enteric Neuroscience, World Gastroenterology Journal, ISRN Gastroenterology, World Journal of Gastrointestinal Pharmacology and Therapeutics (WJGPT), World Journal of Experimental Medicine, and World Journal of Translational Medicine. Dr. Savidge also serves as an invited faculty member of Faculty-of-1000 Medicine, a prestigious post-publication peer review publication that advises the general scientific and medical community on important new clinical practices and scientific advances. Since 1999 Dr. Savidge has served on National Institute of Health Study Sections, Review sections for the American Gastroenterology Association, the Clinical Nutrition Research Center at Harvard, the Broad Foundation and the Research Advisory Committee at UTMB.
Dr. Savidge earned his PhD degree in Molecular Cell Biology from the University of Cambridge, UK. He then did his postdoctoral training in the UK before assuming a faculty position at Harvard Medical School and also served as a Director of the NIH-Clinical Nutrition Research Center at Harvard for 5 years prior to joining UTMB.