Gretchen Mahler

    • Media Contact:
      Ryan Yarosh
    • Member Type(s): Expert
    • Title:Associate Professor of Biomedical Engine
    • Organization:Binghamton University, SUNY Binghamton
    • Area of Expertise:Vitro and in Silico Toxicology

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My Expertise

    My Expertise

      Area(s) of expertise: Vitro and in Silico Toxicology
      Summary of expertise:
      Mahler's research interests include in vitro and in silico toxicology and pharmacology, microfluidic models of organs and tissues, endothelial and epithelial cell pathobiology.
      Blog/Web site:
      White paper/research:
      Mahler's lab uses microfluidics and 3D scaffolds to create physiologically realistic cell culture models of organs and tissues. These in vitro models can be engineered to signal cells using biochemical and biomechanical pathways, help to minimize animal testing, and provide tightly controlled, reproducible experimental conditions. The goal of their work is to replicate some of the cell-cell and cell-extracellular matrix interactions, not easily studied in vivo or in silico, to better understand how cells behave during disease and respond to chemicals or drugs. Current research has applications toward cardiovascular disease and cancer and focuses on how disruptions in a tissue's local mechanical environment can lead to changes in cell phenotype and disease initiation and progression.
      Prior media experience:
      Mahler has been interviewed by publications such as Fox News and, where she has discussed chronic exposure to a common food additive found in everything from chewing gum to bread, and how it can decrease the ability of small intestine cells to absorb nutrients and act as a barrier to pathogens.
      Educational background:
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